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pentobarbital will decrease the extent or effect of netupitant/palonosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; steer clear of use in people who are chronically working with a strong CYP3A4 inducerUse with caution in pregnant Girls and childr